Description

Erythromycin, 6-o-Methyl-2',4'-Bis-o-(Trimethylsilyl)-, 9-[o-(1-Methoxy-1-Methylethyl)Oxime] is a key protected intermediate in the synthesis of advanced macrolide antibiotics and novel semi-synthetic derivatives. This compound is critical for enabling precise chemical modifications to the erythromycin core structure, allowing for the development of new therapeutic agents with improved stability, bioavailability, and efficacy. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of next-generation antibacterial and anti-inflammatory drugs.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel semi-synthetic erythromycin analogs and advanced macrolide antibiotics.
• Antibacterial Drug Development: Used in research to create new compounds targeting resistant bacterial strains by modifying the erythromycin lactone ring.
• Chemical Synthesis Research: Serves as a protected precursor in academic and industrial research exploring new reaction pathways for macrolide functionalization.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for complex active pharmaceutical ingredients (APIs).
• Prodrug Synthesis: Utilized in the development of prodrug forms of erythromycin derivatives to enhance pharmacokinetic properties.

Basic Information

Product Name	Erythromycin, 6-o-Methyl-2',4'-Bis-o-(Trimethylsilyl)-, 9-[o-(1-Methoxy-1-Methylethyl)Oxime]
CAS No.	119699-81-9
Molecular Formula	C41H75N2O9Si2
Molecular Weight	812.3 g/mol
Synonyms	Erythromycin 9-[O-(1-Methoxy-1-methylethyl)oxime], 6-O-Methyl-2',4'-bis-O-(trimethylsilyl)-; 6-O-Methylerythromycin 9-[O-(1-methoxy-1-methylethyl)oxime] 2',4'-bis(trimethylsilyl) ether; 2',4'-Bis-O-(trimethylsilyl)-6-O-methylerythromycin 9-(O-(1-methoxy-1-methylethyl)oxime); Protected 6-O-Methyl Erythromycin Oxime; TMS-protected Erythromycin Derivative
EINECS	Contact for details

Quality Control

Our Erythromycin, 6-o-Methyl-2',4'-Bis-o-(Trimethylsilyl)-, 9-[o-(1-Methoxy-1-Methylethyl)Oxime] is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.