Description

2'-Oxo Ifosfamide is a key intermediate and metabolite in the synthesis and metabolic pathway of the antineoplastic agent ifosfamide. This compound is of critical importance for pharmaceutical research and development, particularly in the study of drug metabolism, mechanism of action, and the synthesis of novel chemotherapeutic agents. It is primarily utilized by research institutions, pharmaceutical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in oncology drug development and analytical method validation.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis and process development of the chemotherapeutic drug ifosfamide.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies to quantify and characterize the metabolic profile of ifosfamide in biological matrices.
• Pharmacology Research: Employed in preclinical and clinical research to investigate the pharmacokinetics, pharmacodynamics, and activation pathways of oxazaphosphorine drugs.
• Impurity Standard: Serves as a certified reference material for the identification and control of related substances in ifosfamide active pharmaceutical ingredient (API) and finished drug products.
• Process Chemistry: Used in the development and optimization of synthetic routes for oxazaphosphorine-class compounds.
• Drug Discovery: A potential starting point for the design and synthesis of new analogs with modified therapeutic profiles.

Basic Information

Product Name	2'-Oxo Ifosfamide
CAS No.	119670-13-2
Molecular Formula	C7H15Cl2N2O2P
Molecular Weight	261.09 g/mol
Synonyms	4-Hydroperoxy-ifosfamide; Ifosfamide 4-Hydroperoxide; NSC 338720; 3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-Oxide 4-Hydroperoxide; 2'-Oxoifosfamide; 4-Hydroperoxyifosfamide; Ifosfamide Metabolite
EINECS	Contact for details

Quality Control

Our 2'-Oxo Ifosfamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity determination by HPLC, and control of specific impurities. A Certificate of Analysis (COA) detailing all test results against established specifications is provided with every shipment to ensure traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single unknown impurity ≤ 1.0%
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.