Description

n-(Indan-2-Yl)Glycine Benzyl Ester is a high-purity, non-natural amino acid derivative featuring a benzyl-protected carboxyl group and an indane-based side chain. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, offering a versatile scaffold for constructing complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical development teams engaged in the creation of novel active pharmaceutical ingredients (APIs), peptide mimetics, and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) targets.
• Peptidomimetics & Constrained Peptide Design: The indane moiety provides conformational rigidity, making it valuable for designing bioactive peptide analogs with enhanced metabolic stability.
• Asymmetric Synthesis: Used as a starting material or auxiliary in catalytic asymmetric reactions to introduce stereogenic centers.
• Chemical Biology & Proteomics: Employed in the synthesis of specialized amino acid analogs for probing enzyme mechanisms or protein-protein interactions.
• Ligand & Catalyst Development: The structure serves as a precursor for creating novel chelating ligands and organocatalysts.
• Academic & Industrial R&D: Fundamental research in medicinal chemistry and synthetic methodology development.

Basic Information

Item	Details
Product Name	n-(Indan-2-Yl)Glycine Benzyl Ester
CAS No.	119543-21-4
Molecular Formula	C18H19NO2
Molecular Weight	281.35 g/mol
Synonyms	Benzyl 2-[(2,3-dihydro-1H-inden-2-yl)amino]acetate; (Indan-2-ylamino)-acetic acid benzyl ester; Glycine, N-(2,3-dihydro-1H-inden-2-yl)-, benzyl ester; N-(2,3-Dihydro-1H-inden-2-yl)glycine benzyl ester; Benzyl N-(indan-2-yl)glycinate; 2-[(2,3-Dihydro-1H-inden-2-yl)amino]acetic Acid Benzyl Ester
EINECS	Contact for details

Quality Control

Our n-(Indan-2-Yl)Glycine Benzyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and spectroscopic identification (NMR, IR, MS), to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee (by chiral HPLC)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.