Description

L-Isoleucine T-Butyl Ester Hydrochloride is a protected amino acid derivative essential for advanced organic synthesis. This compound is a critical chiral building block for the controlled construction of peptides and complex bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics and fine chemical intermediates.

Application

• Peptide Synthesis: Serves as a key chiral intermediate in solid-phase and solution-phase peptide synthesis (SPPS), protecting the carboxylic acid group of L-isoleucine.
• Pharmaceutical Intermediates: Used in the research and production of active pharmaceutical ingredients (APIs) and prodrugs requiring specific stereochemistry.
• Bioconjugation & Labeling: Acts as a precursor for creating modified amino acids used in bioconjugation chemistry for drug delivery systems or diagnostic agents.
• Chemical Biology Research: Employed in the synthesis of peptide mimetics, enzyme inhibitors, and other biologically active probes for biochemical studies.
• Fine Chemical Production: Utilized as a high-purity building block in the multi-step synthesis of complex organic molecules for agrochemicals and specialty materials.

Basic Information

Product Name	L-Isoleucine T-Butyl Ester Hydrochloride
CAS No.	119483-46-4
Molecular Formula	C₁₀H₂₁NO₂·HCl
Molecular Weight	223.74 g/mol (Free base: 187.28 g/mol)
Synonyms	L-Isoleucine tert-Butyl Ester Hydrochloride; (2S,3S)-2-Amino-3-methylpentanoic acid 1,1-dimethylethyl ester hydrochloride; H-Ile-OtBu·HCl; tert-Butyl L-isoleucinate hydrochloride; (S,S)-Isoleucine t-butyl ester HCl; L-Ile-OtBu HCl; Boc-Ile-OtBu precursor; Isoleucine t-butyl ester HCl salt
EINECS	Contact for details

Quality Control

Our L-Isoleucine T-Butyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee consistent quality and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.