Description

N(6)-(N((4-Azido-3,5,6-Trifluoro)Pyridin-2-Yl)-2-Aminoethyl)Adenosine 5'-Monophosphate is a chemically modified nucleotide analog designed for advanced biochemical research and development. This compound is highly valued for its unique bifunctional structure, which incorporates a photoreactive azido group and a fluorinated pyridine moiety, enabling precise cross-linking and labeling applications. It is primarily utilized by researchers and process developers in the pharmaceutical and biotechnology sectors for probing nucleotide-protein interactions, developing targeted therapeutics, and creating novel diagnostic assays.

Application

• Photoaffinity Labeling Probe: Used to covalently tag and identify adenosine monophosphate (AMP) binding sites on proteins and enzymes through UV-induced cross-linking.
• Bioconjugation & Linker Chemistry: Serves as a critical intermediate for synthesizing nucleotide-protein or nucleotide-small molecule conjugates for targeted drug delivery systems.
• Enzymology & Mechanism Studies: Employed as a substrate analog or inhibitor to study the kinetics and mechanisms of kinases, phosphorylases, and other nucleotide-processing enzymes.
• Diagnostic Assay Development: Integral in the design of high-sensitivity detection kits and biosensors for monitoring cellular ATP/AMP levels or specific enzymatic activities.
• Chemical Biology Tool: Facilitates the study of purinergic signaling pathways and the development of activity-based probes for proteomic research.
• Precision Medicine Research: Supports the development of novel therapeutic agents targeting nucleotide-dependent processes in oncology, immunology, and metabolic diseases.

Basic Information

Product Name	N(6)-(N((4-Azido-3,5,6-Trifluoro)Pyridin-2-Yl)-2-Aminoethyl)Adenosine 5'-Monophosphate
CAS No.	119304-29-9
Molecular Formula	C₁₈H₁₉F₃N₁₀O₇P
Molecular Weight	590.38 g/mol
Synonyms	6-[(2-[(4-Azido-3,5,6-trifluoropyridin-2-yl)amino]ethyl)amino]-9-β-D-ribofuranosyl-9H-purine 5'-monophosphate; 2'-Deoxy-N6-[2-[(4-azido-3,5,6-trifluoro-2-pyridinyl)amino]ethyl]adenosine-5'-monophosphate; 5'-AMP-N6-azido-PEG2-C2-amine analog; Azido-TFP-Adenosine-5'-monophosphate; Photoactivatable AMP analog; N6-(2-((4-Azido-3,5,6-trifluoropyridin-2-yl)amino)ethyl)adenosine 5'-monophosphate
EINECS	Contact for details

Quality Control

Our production of N(6)-(N((4-Azido-3,5,6-Trifluoro)Pyridin-2-Yl)-2-Aminoethyl)Adenosine 5'-Monophosphate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, critical for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, store under inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.