Description

1H-Imidazole-4-Carboxylic Acid, 4,5-Dihydro-2-[[[(Phenylmethoxy)Carbonyl]Amino]Methyl]-, Methyl Ester, (S)- is a high-purity, chiral imidazole derivative serving as a critical advanced pharmaceutical intermediate for the synthesis of complex active pharmaceutical ingredients (APIs). Its value lies in its role as a sophisticated building block, enabling the construction of molecules with specific stereochemistry and functional groups essential for modern drug discovery. This compound is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for targeted therapies.
• Protease Inhibitor Synthesis: Used in constructing complex molecular scaffolds for enzyme inhibitors.
• Peptidomimetic Chemistry: Serves as a constrained amino acid analog in the design of peptide-like bioactive compounds.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in stereoselective chemical reactions.
• Medicinal Chemistry Research: Utilized in structure-activity relationship (SAR) studies and lead optimization processes.
• Bioconjugation & Labeling Reagent: Potential use in creating specialized reagents for biochemical applications.

Basic Information

Product Name	1H-Imidazole-4-Carboxylic Acid, 4,5-Dihydro-2-[[[(Phenylmethoxy)Carbonyl]Amino]Methyl]-, Methyl Ester, (S)-
CAS No.	119140-50-0
Molecular Formula	C14H17N3O4
Molecular Weight	291.30 g/mol
Synonyms	(S)-Methyl 2-((((benzyloxy)carbonyl)amino)methyl)-4,5-dihydro-1H-imidazole-4-carboxylate; (S)-Cbz-Aspartic Acid β-Methyl Ester Imidazoline; (S)-2-[(Z-Amino)methyl]-4,5-dihydro-1H-imidazole-4-carboxylic Acid Methyl Ester; (S)-2-[[(Benzyloxycarbonyl)amino]methyl]-4,5-dihydro-1H-imidazole-4-carboxylic Acid Methyl Ester; (S)-2-(Cbz-aminomethyl)-2-imidazoline-4-carboxylic Acid Methyl Ester; (S)-Cbz-Aspartic Acid β-Methyl Ester Cyclic Imide; Z-D-Asp(OMe)-Imidazoline; A Chiral Imidazoline Derivative
EINECS	Contact for details

Quality Control

Our production of this high-purity intermediate adheres to stringent quality protocols suitable for pharmaceutical R&D. Each batch undergoes comprehensive analytical characterization, including HPLC for purity and chiral analysis to confirm enantiomeric excess. We provide full traceability and detailed Certificates of Analysis (COA) upon request, ensuring compliance with the exacting standards required for advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive; the container should be kept tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.