Description

Chlorambucil-Tertiary Butyl Ester is a key pharmaceutical intermediate and a protected derivative of the alkylating agent chlorambucil. This compound is strategically important for the synthesis and research of nitrogen mustard-based chemotherapeutic agents, offering enhanced stability and handling properties for advanced manufacturing processes. It is primarily utilized by pharmaceutical R&D laboratories, API (Active Pharmaceutical Ingredient) manufacturers, and fine chemical synthesis specialists working in oncology drug development and related life science fields.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of chlorambucil and its prodrug analogs for cancer therapy.
• Oncology Research: Used in biochemical and pharmacological studies to investigate the mechanisms of alkylating agents.
• Prodrug Development: Serves as a precursor for designing targeted or masked forms of chemotherapeutic agents to improve selectivity and reduce side effects.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses requiring a protected nitrogen mustard functionality.
• Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and impurity profiling.

Basic Information

Product Name	Chlorambucil-Tertiary Butyl Ester
CAS No.	119054-09-0
Molecular Formula	C14H21Cl2NO2
Molecular Weight	306.23 g/mol
Synonyms	4-[Bis(2-chloroethyl)amino]benzenebutanoic acid 1,1-dimethylethyl ester; tert-Butyl 4-[bis(2-chloroethyl)amino]phenylbutyrate; Chlorambucil tert-butyl ester; Chlorambucil t-butyl ester; NSC 757680; tert-Butyl chlorambucil ester
EINECS	Contact for details

Quality Control

Our Chlorambucil-Tertiary Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.