Description

Ethyl 2-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)acetate is a specialized polyethylene glycol (PEG) derivative ester, characterized by its hydrophilic oligo(ethylene glycol) chain terminated with a hydroxyl group and an ethyl acetate moiety. This unique bifunctional structure makes it a valuable versatile building block and solubilizing agent in advanced chemical synthesis. It is primarily sought after by R&D and production teams in the pharmaceutical, cosmetic, and specialty polymer industries for its ability to impart water solubility and modify physicochemical properties.

Application

• Pharmaceutical Intermediate: Used in the synthesis of prodrugs, drug conjugates, and PEGylated active pharmaceutical ingredients (APIs) to enhance solubility, bioavailability, and circulation time.
• Polymer Chemistry: Serves as a monomer or functional initiator/terminator in the production of hydrophilic, biodegradable, and stimuli-responsive polymers and hydrogels.
• Cosmetic & Personal Care Formulations: Acts as a non-ionic surfactant, emulsifier, or moisturizing agent in creams, lotions, and serums due to its humectant and skin-conditioning properties.
• Bioconjugation Linker: Provides a spacer arm for attaching dyes, probes, or targeting molecules to proteins, peptides, and other biomolecules in diagnostic and research applications.
• Surface Modification: Used to create hydrophilic, protein-resistant, or non-fouling coatings on medical devices, sensors, and nanomaterials.
• Solubility Enhancer: Employed in formulation science to improve the aqueous solubility of poorly soluble compounds in various delivery systems.

Basic Information

Item	Details
Product Name	Ethyl 2-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)acetate
CAS No.	118988-04-8
Molecular Formula	C12H24O7
Molecular Weight	280.31 g/mol
Synonyms	Ethyl tetraethylene glycol acetate; 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl acetate; Acetic acid, 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, ethyl ester; Tetraethylene glycol monoethyl ether acetate; HO-PEG4-CH2COOEt; Ethyl Oxybis(ethane-2,1-diyl) Oxybis(ethane-2,1-diyl) 2-acetate
EINECS	Contact for details

Quality Control

Our Ethyl 2-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)acetate is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including assay by GC/HPLC, identity confirmation (IR, NMR), and determination of critical impurities and water content. Certificates of Analysis (COA) documenting all test results are provided and available upon request to ensure full traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize moisture uptake and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Acid Value	≤ 1.0 mg KOH/g
Refractive Index (n20D)	1.450 - 1.455
Density (g/mL, 20°C)	1.10 - 1.15

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.