Description

2,6-Bis((S)-4-((S)-sec-Butyl)-4,5-Dihydrooxazol-2-Yl)Pyridine is a high-purity, chiral bis(oxazoline) ligand, a critical class of compounds in asymmetric synthesis. Its value lies in its ability to act as a highly selective and efficient catalyst or ligand in the formation of carbon-carbon and carbon-heteroatom bonds, enabling the production of enantiomerically pure intermediates. This product is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for advanced molecule synthesis.

Application

• Asymmetric Catalysis: Serving as a privileged chiral ligand in transition metal-catalyzed reactions such as Diels-Alder cycloadditions, cyclopropanations, and aldol reactions.
• Pharmaceutical Intermediates: Facilitating the enantioselective synthesis of active pharmaceutical ingredients (APIs) and complex chiral building blocks.
• Agrochemical Synthesis: Enabling the production of chiral herbicides, fungicides, and insecticides with enhanced biological activity and environmental profile.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, flavors, and fragrances where optical purity is paramount.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry and process optimization in pilot plants.
• Material Science: Potential applications in the synthesis of chiral polymers and advanced functional materials.

Basic Information

Product Name	2,6-Bis((S)-4-((S)-sec-Butyl)-4,5-Dihydrooxazol-2-Yl)Pyridine
CAS No.	118949-62-5
Molecular Formula	C21H31N3O2
Molecular Weight	357.49 g/mol
Synonyms	(S,S)-2,6-Bis(4-sec-butyl-4,5-dihydrooxazol-2-yl)pyridine; (S,S)-2,6-Bis(4-(1-methylpropyl)-2-oxazolin-2-yl)pyridine; PyBOX ligand with (S)-sec-butyl substituents; (S,S)-Di-sec-butyl-PyBOX; Chiral bis(oxazoline) ligand; 2,6-Pyridinediylbis[4,5-dihydro-4-((1S)-1-methylpropyl)-2-oxazole]; (S,S)-2,6-Bis[4-(sec-butyl)-4,5-dihydrooxazol-2-yl]pyridine
EINECS	Contact for details

Quality Control

Our 2,6-Bis((S)-4-((S)-sec-Butyl)-4,5-Dihydrooxazol-2-Yl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure high enantiomeric excess (ee) and chemical purity suitable for demanding catalytic applications. Certificates of Analysis (COA) detailing identity, purity, and specific tests are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.