Description

2-Chloro-6-Methylphenyl Isocyanide is a versatile aromatic isocyanide building block essential for the synthesis of heterocyclic compounds and complex organic molecules. Its high reactivity makes it a critical reagent for constructing pharmacophores and advanced materials. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for lead optimization and novel material creation.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of heterocyclic drug candidates, particularly for oncology and central nervous system (CNS) targets.
• Agrochemical Synthesis: Used in the development of novel fungicides and herbicides, leveraging its isocyanide functionality for multi-component reactions.
• Ligand & Catalyst Development: Serves as a building block for creating specialized N-heterocyclic carbene (NHC) ligands and organometallic catalysts.
• Material Science Research: Employed in the synthesis of functional polymers and metal-organic frameworks (MOFs) with tailored properties.
• Multicomponent Reactions (MCRs): A valuable reactant in Ugi, Passerini, and related isocyanide-based multicomponent reactions for rapid library synthesis.

Basic Information

Product Name	2-Chloro-6-Methylphenyl Isocyanide
CAS No.	118923-96-9
Molecular Formula	C8H6ClN
Molecular Weight	151.59 g/mol
Synonyms	2-Chloro-6-methylphenyl isocyanide; 2-Chloro-6-methylbenzenecarbonitrile; 1-Chloro-2-isocyano-3-methylbenzene; 2-Chloro-6-methylphenylisonitrile; (2-Chloro-6-methylphenyl)isocyanide; 2-Chloro-6-methylbenzenisonitrile; 2-Chloro-6-methylphenyl isonitrile; 2-Chloro-6-methylbenzenecarbonitrile
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-Methylphenyl Isocyanide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure a minimum purity of 97% and consistent performance. Certificates of Analysis (COA) with full traceability are provided for all shipments, ensuring compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation. The container should be kept in a cool, dry, and well-ventilated area, away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.