Description

2,3-Dibromopropionyl-n-Hydroxysuccinimide Ester (CAS NO 118790-78-6) is a highly reactive bifunctional cross-linking agent and a key intermediate in organic synthesis. This compound matters for its ability to introduce bromoacetyl groups into target molecules, facilitating the creation of stable conjugates under mild conditions. It is primarily needed by researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors for developing novel drug delivery systems, diagnostic reagents, and functional polymers.

Application

• Bioconjugation Reagent: Used for the covalent attachment of peptides, proteins, or oligonucleotides to surfaces, carriers, or other biomolecules.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs.
• Polymer Modification: Enables the functionalization of polymers and dendrimers to impart specific chemical or biological properties.
• Affinity Chromatography Ligand Synthesis: Employed in the preparation of immobilized ligands for protein purification and separation.
• Diagnostic Probe Development: Facilitates the labeling of antibodies, antigens, or other probes for immunoassays and biosensors.
• Cross-linking Agent: Used to create cross-linked hydrogels, polymer networks, and biomaterial scaffolds with controlled properties.
• Surface Chemistry: Applied for the modification of gold nanoparticles, quantum dots, and other nanomaterials for biomedical applications.
• Research & Development: A versatile tool in chemical biology and medicinal chemistry for exploring new molecular interactions and pathways.

Basic Information

Product Name	2,3-Dibromopropionyl-n-Hydroxysuccinimide Ester
CAS No.	118790-78-6
Molecular Formula	C7H7Br2NO4
Molecular Weight	328.94 g/mol
Synonyms	2,3-Dibromopropionic Acid N-Hydroxysuccinimide Ester; 2,3-Dibromopropionyl NHS Ester; N-(2,3-Dibromopropionyloxy)succinimide; DBPA-NHS; 2,3-Dibromo-1-oxopropan-2-yl 2,5-dioxopyrrolidine-1-carboxylate; Succinimidyl 2,3-dibromopropionate; 2,3-Dibromopropanoyloxysuccinimide
EINECS	Contact for details

Quality Control

Our 2,3-Dibromopropionyl-n-Hydroxysuccinimide Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and industrial applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.