Description

Ethyl 4-Methylpyroglutamate is a high-purity chiral building block and synthetic intermediate of significant importance in advanced organic synthesis. Its value lies in its role as a key precursor for the preparation of pharmaceutical compounds, particularly those with neurological activity. This product is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for complex molecule construction.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of nootropic agents, cognitive enhancers, and other central nervous system (CNS) active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and production of advanced, biologically active compounds for crop protection.
• Fine Chemical Building Block: Serves as a versatile precursor in custom synthesis and the development of novel chemical entities for various research applications.
• Peptidomimetics Research: Employed in the design and synthesis of peptide analogs and conformationally constrained amino acid derivatives.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in catalytic asymmetric reactions to introduce stereogenic centers.

Basic Information

Product Name	Ethyl 4-Methylpyroglutamate
CAS No.	118767-38-7
Molecular Formula	C8H13NO3
Molecular Weight	171.19 g/mol
Synonyms	Ethyl (S)-4-Methyl-5-oxopyrrolidine-2-carboxylate; (S)-(-)-Ethyl 4-Methyl-2-pyrrolidinone-5-carboxylate; L-4-Methylpyroglutamic Acid Ethyl Ester; Ethyl L-4-Methyl-5-oxoproline; Ethyl (S)-4-Methyl-5-oxo-2-pyrrolidinecarboxylate; 4-Methyl-DL-pyroglutamic Acid Ethyl Ester; Ethyl 4-Methyl-2-oxopyrrolidine-5-carboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 4-Methylpyroglutamate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity assessment, to meet the stringent requirements of pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee (S-enantiomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.