Description

Triethyl Orthoformate (Formyl-13C) is a stable, isotopically labeled derivative of triethyl orthoformate, where the formyl carbon is the carbon-13 isotope. This compound is a critical reagent for introducing a 13C-labeled formyl group or ethoxycarbonyl group in complex synthetic pathways, enabling precise tracking and analysis in research. It is primarily utilized by pharmaceutical researchers, agrochemical developers, and advanced material scientists working in isotope labeling, NMR spectroscopy, and the synthesis of labeled APIs and intermediates.

Application

• Pharmaceutical Research & Development: Key building block for the synthesis of Carbon-13 labeled Active Pharmaceutical Ingredients (APIs) and complex drug intermediates for metabolic studies.
• NMR Spectroscopy & Analytical Standards: Serves as an internal standard or a precursor for creating 13C-labeled compounds used as probes in nuclear magnetic resonance (NMR) spectroscopy.
• Agrochemical Synthesis: Used in the development of isotopically labeled pesticides, herbicides, and their metabolites for environmental fate and metabolism studies.
• Organic Synthesis & Methodology: Employed as a protected formyl anion equivalent and a versatile ethoxycarbonylation reagent in multi-step synthetic sequences.
• Material Science: Potential precursor in the synthesis of specialty polymers and advanced organic materials where isotopic purity is required.

Basic Information

Product Name	Triethyl Orthoformate (Formyl-13C)
CAS No.	118659-62-4
Molecular Formula	C13HC7H15O3 or C7H1513CO3
Molecular Weight	149.19 g/mol (for 13C1 isotopologue)
Synonyms	1,1,1-Triethoxy(13C)methane; Ethyl Orthoformate-13C; Triethoxy(13C)methane; Orthoformic Acid Triethyl Ester (Formyl-13C); Formic Acid, Ortho-, Triethyl Ester-13C; HC(OEt)3-13C; Triethyl 13C-Orthoformate
EINECS	Contact for details

Quality Control

Our isotopically labeled chemicals are produced and handled under strict quality protocols to ensure high chemical and isotopic purity. Each batch is characterized by advanced analytical techniques including NMR, GC-MS, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing assay, isotopic enrichment, and impurity profile is provided with every shipment to support your research and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent degradation.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Isotopic Enrichment (13C)	≥ 99 atom % 13C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.