Description

2-Furanpropanoic Acid, Alpha,α-Difluoro-β-Oxo-, Ethyl Ester (9Ci) is a specialized fluorinated furan derivative, a high-value building block in advanced organic synthesis. Its core value lies in its unique molecular structure, which incorporates both a reactive β-ketoester moiety and difluoromethyl groups, making it a critical intermediate for constructing complex molecules with tailored properties. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to introduce fluorinated motifs to enhance metabolic stability, bioavailability, and biological activity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in developing fluorinated drug candidates for oncology, CNS disorders, and metabolic diseases.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorine atoms improve lipophilicity, membrane permeability, and environmental stability.
• Material Science Research: Serves as a precursor for fluorinated organic materials, including specialty polymers, liquid crystals, and electronic chemicals.
• Chemical Biology & Probe Development: Utilized in designing fluorinated molecular probes and tags for studying biological mechanisms and diagnostic applications.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial production of fluorinated fine chemicals.

Basic Information

Product Name	2-Furanpropanoic Acid, Alpha,α-Difluoro-β-Oxo-, Ethyl Ester (9Ci)
CAS No.	118460-56-3
Molecular Formula	C10H10F2O4
Molecular Weight	232.18 g/mol
Synonyms	Ethyl 2,2-difluoro-3-oxo-3-(2-furyl)propanoate; 3-(2-Furanyl)-2,2-difluoro-3-oxopropanoic Acid Ethyl Ester; Ethyl 3-(furan-2-yl)-2,2-difluoro-3-oxopropanoate; 2,2-Difluoro-3-oxo-3-(2-furyl)propionic Acid Ethyl Ester; DFOP Ethyl Ester; 118460-56-3; 9CI Index Name Compound
EINECS	Contact for details

Quality Control

Every batch of our 2-Furanpropanoic Acid, Alpha,α-Difluoro-β-Oxo-, Ethyl Ester (9Ci) undergoes rigorous analytical testing to ensure it meets the stringent purity and consistency requirements for advanced synthetic applications. Our quality assurance protocols are designed to support cGMP and ISO standards where applicable. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee supply chain transparency and research reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.