Description

Methyl n-Succinimidyl Adipate is a specialized bifunctional crosslinking reagent featuring both an N-hydroxysuccinimide (NHS) ester and a methyl ester group. This molecular structure is critical for its primary role in bioconjugation, enabling the stable and efficient coupling of biomolecules under mild aqueous conditions. It is an essential intermediate for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing advanced therapeutics, diagnostics, and research reagents.

Application

• Bioconjugation and Protein Labeling: Used to covalently link proteins, antibodies, or peptides to other molecules, such as drugs, fluorophores, or solid supports, via primary amine groups.
• Antibody-Drug Conjugate (ADC) Synthesis: Serves as a key linker component in the development of targeted cancer therapies, connecting cytotoxic payloads to monoclonal antibodies.
• Biomaterial and Hydrogel Fabrication: Employed to crosslink amine-containing polymers (e.g., chitosan, gelatin) to create scaffolds for tissue engineering and drug delivery systems.
• Diagnostic Assay Development: Facilitates the immobilization of capture antibodies or antigens onto microplates, beads, or sensor surfaces for ELISA, lateral flow assays, and biosensors.
• PEGylation and Polymer Modification: Acts as a functional handle for attaching polyethylene glycol (PEG) or other polymers to therapeutic proteins to enhance stability and pharmacokinetics.
• Affinity Chromatography Ligand Coupling: Used to attach specific ligands to chromatography resins for the purification of target biomolecules.

Basic Information

Product Name	Methyl n-Succinimidyl Adipate
CAS No.	118380-06-6
Molecular Formula	C11H15NO6
Molecular Weight	257.24 g/mol
Synonyms	6-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-6-oxohexanoic acid methyl ester; Methyl 6-[(2,5-dioxo-1-pyrrolidinyl)oxy]-6-oxohexanoate; NHS-Adipate-OMe; Adipic acid N-hydroxysuccinimide ester methyl ester; Methyl ester of N-succinimidyl adipate; Succinimidyl adipate methyl ester; N-Succinimidyl methyl adipate
EINECS	Contact for details

Quality Control

Our Methyl n-Succinimidyl Adipate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the high standards required for sensitive bioconjugation applications. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment. We support cGMP-grade production for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and hydrolysis. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.