Description

(3''As,4''R,5''R,6''Ar)-Hexahydro-5''-Hydroxy-5,5-Dimethyl-Spiro[1,3-Dioxane-2,2''(1''H)-Pentalene]-4''-Carboxylic Acid Methyl Ester is a high-purity, complex spirocyclic compound with a defined stereochemistry, serving as a critical chiral building block and advanced pharmaceutical intermediate. Its precise molecular architecture makes it invaluable for the synthesis of novel active pharmaceutical ingredients (APIs) and fine chemicals requiring specific three-dimensional orientation. This compound is primarily targeted at research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries engaged in process development and high-value synthesis.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new therapeutic agents, particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Asymmetric Synthesis: Utilized as a sophisticated building block in stereoselective organic synthesis to construct complex molecular frameworks.
• Agrochemical Research: Serves as a precursor in the development of novel, high-efficacy pesticides and herbicides with specific activity profiles.
• Chemical Biology Probes: Used in academic and industrial research to create molecular probes for studying enzyme mechanisms and biological pathways.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Fine Chemical Manufacturing: Integral component in the multi-step synthesis of specialty chemicals and performance materials.

Basic Information

Item	Detail
Product Name	(3''As,4''R,5''R,6''Ar)-Hexahydro-5''-Hydroxy-5,5-Dimethyl-Spiro[1,3-Dioxane-2,2''(1''H)-Pentalene]-4''-Carboxylic Acid Methyl Ester
CAS No.	118375-00-1
Molecular Formula	C15H22O5
Molecular Weight	282.33 g/mol
Synonyms	Methyl (3aR,4R,5R,6aR)-Hexahydro-5-hydroxy-5,5-dimethyl-spiro[1,3-dioxane-2,2'(1'H)-pentalene]-4-carboxylate; Spiro[1,3-dioxane-2,2'(1'H)-pentalene]-4'-carboxylic Acid, Hexahydro-5'-hydroxy-5,5-dimethyl-, Methyl Ester, (3'α,4'R,5'R,6'α)-; CAS 118375-00-1; Advanced Spirocyclic Ester; Chiral Spiro Building Block
EINECS	Contact for details

Quality Control

Every batch of (3''As,4''R,5''R,6''Ar)-Hexahydro-5''-Hydroxy-5,5-Dimethyl-Spiro[1,3-Dioxane-2,2''(1''H)-Pentalene]-4''-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and stereochemical purity compliant with research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.