Description

3-Methoxy-2-Trimethylsilylpyridine is a versatile organosilicon-protected pyridine derivative, serving as a key synthetic intermediate in advanced organic synthesis. Its primary value lies in its dual functionality, where the trimethylsilyl group acts as a protective and directing group, while the methoxy-substituted pyridine ring provides a reactive heterocyclic scaffold. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for constructing complex molecules, developing novel active ingredients, and facilitating challenging coupling reactions.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting the central nervous system.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its pyridine core.
• Ligand and Catalyst Precursor: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis and cross-coupling reactions.
• Material Science Research: Employed in the creation of organic semiconductors, liquid crystals, and other functional materials due to its electron-donating methoxy group.
• Custom Synthesis and Process R&D: A valuable reagent for contract research organizations (CROs) and fine chemical manufacturers for developing scalable synthetic routes.
• Protecting Group Strategy: The trimethylsilyl group is used to temporarily protect reactive sites on the pyridine ring during multi-step syntheses.

Basic Information

Product Name	3-Methoxy-2-Trimethylsilylpyridine
CAS No.	118005-97-3
Molecular Formula	C9H15NOSi
Molecular Weight	181.31 g/mol
Synonyms	2-(Trimethylsilyl)-3-methoxypyridine; 3-Methoxy-2-(trimethylsilyl)pyridine; Pyridine, 3-methoxy-2-(trimethylsilyl)-; 2-Trimethylsilyl-3-methoxypyridine; 3-Methoxypyridine-2-trimethylsilane
EINECS	Contact for details

Quality Control

Our 3-Methoxy-2-Trimethylsilylpyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.