Description

4-(tert-Butyl-Dimethyl-Silanyloxy)-But-2-Ynoic Acid Methyl Ester is a protected alkyne derivative, a key building block in advanced organic synthesis. Its value lies in the tert-butyldimethylsilyl (TBDMS) protecting group, which shields the hydroxyl functionality during complex multi-step reactions, enabling precise molecular construction. This compound is essential for researchers and manufacturers in pharmaceutical development and fine chemical production, particularly for creating complex molecules like active pharmaceutical ingredients (APIs) and specialty materials.

Application

• Pharmaceutical Intermediate: A critical synthon for the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Peptide & Nucleotide Chemistry: Used in the preparation of modified amino acids and nucleosides where hydroxyl group protection is required.
• Natural Product Synthesis: Serves as a building block in the total synthesis of complex natural products with alkyne and ester functionalities.
• Material Science Research: Employed in the development of novel polymers and advanced organic materials with specific functional properties.
• Cross-Coupling Reactions: Acts as a substrate in Sonogashira and other palladium-catalyzed cross-coupling reactions to form complex carbon-carbon bonds.
• Chemical Biology Probes: Utilized in the creation of tagged molecules and probes for studying biological systems.

Basic Information

Product Name	4-(tert-Butyl-Dimethyl-Silanyloxy)-But-2-Ynoic Acid Methyl Ester
CAS No.	117968-51-1
Molecular Formula	C11H20O3Si
Molecular Weight	228.36 g/mol
Synonyms	Methyl 4-[(tert-butyldimethylsilyl)oxy]but-2-ynoate; 4-[(tert-Butyldimethylsilyl)oxy]-2-butynoic Acid Methyl Ester; Methyl 4-(TBDMS-oxy)but-2-ynoate; TBDMS-protected Butynoic Acid Methyl Ester; 4-(TBDMSO)but-2-ynoic Acid Methyl Ester; Methyl 4-((tert-butyldimethylsilyl)oxy)but-2-ynoate; 4-(tert-Butyldimethylsiloxy)-2-butynoic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our 4-(tert-Butyl-Dimethyl-Silanyloxy)-But-2-Ynoic Acid Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.