Description

(2S,5R)-5-Hydroxy-1,2-Piperidinedicarboxylic Acid 2-Methyl 1-Benzyl Ester is a high-purity chiral piperidine derivative, a critical building block in advanced organic synthesis. This compound matters for its role as a sophisticated intermediate in the development of active pharmaceutical ingredients (APIs) and other fine chemicals requiring precise stereochemistry. Pharmaceutical research and development teams, as well as specialty chemical manufacturers, need this material to create complex molecules with specific biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly those targeting the central nervous system or with protease inhibitor activity.
• Asymmetric Synthesis: Utilized as a building block for constructing molecules with defined stereocenters, essential for creating enantiomerically pure compounds.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Peptidomimetic Development: Used in the design and synthesis of peptidomimetics, which are molecules that mimic peptides but with improved stability and bioavailability.
• Catalyst Ligand Precursor: Can be modified to form chiral ligands for asymmetric catalysis, enabling more efficient and selective chemical transformations.
• Reference Standard: Employed as an analytical standard for quality control and method development in pharmaceutical manufacturing.

Basic Information

Product Name	(2S,5R)-5-Hydroxy-1,2-Piperidinedicarboxylic Acid 2-Methyl 1-Benzyl Ester
CAS No.	117836-27-8
Molecular Formula	C16H19NO6
Molecular Weight	321.33 g/mol
Synonyms	5-Hydroxypipecolic Acid 1-Benzyl 2-Methyl Ester; (2S,5R)-1-Benzyl 2-Methyl 5-Hydroxy-1,2-piperidinedicarboxylate; 1-Benzyl 2-Methyl (2S,5R)-5-Hydroxypipecolate; (2S,5R)-5-Hydroxypipecolic Acid Benzyl Methyl Ester; L-threo-5-Hydroxypipecolic Acid 1-Benzyl 2-Methyl Ester; (2S,5R)-1-(Benzyloxycarbonyl)-5-hydroxy-2-(methoxycarbonyl)piperidine; A Chiral Pipecolic Acid Derivative
EINECS	Contact for details

Quality Control

Our (2S,5R)-5-Hydroxy-1,2-Piperidinedicarboxylic Acid 2-Methyl 1-Benzyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.