Description

(4-Azido-2-Nitrophenyl)-5-Acetamido-2,3,5-Trideoxy-2-Thioglycerogalacto-2-Nonulopyranosidonic Acid CAS NO 117681-72-8 is a specialized, high-purity biochemical reagent featuring a unique azido-nitrophenyl functional group linked to a modified sialic acid derivative. This compound is critical for advanced research and development in glycobiology and bioconjugation chemistry, enabling precise labeling and cross-linking of biomolecules. It is primarily utilized by pharmaceutical R&D teams, diagnostic developers, and academic researchers focused on carbohydrate-based drug discovery, vaccine development, and advanced assay design.

Application

• Bioconjugation & Click Chemistry: Acts as a key reagent for site-specific labeling of proteins, antibodies, and other biomolecules via azide-alkyne cycloaddition (CuAAC) reactions.
• Glycobiology Research: Used as a substrate or inhibitor in studies of sialidases (neuraminidases) and sialyltransferases to understand glycan-mediated biological processes.
• Diagnostic Probe Development: Serves as a precursor for synthesizing fluorescent or chemiluminescent probes for detecting carbohydrate-binding proteins or specific cell surface glycans.
• Vaccine & Drug Discovery: Employed in the design and synthesis of novel sialic acid-based vaccine candidates or therapeutic agents targeting pathogens and cancers.
• Surface Modification: Used to functionalize biosensor chips, nanoparticles, or microarray surfaces with specific carbohydrate epitopes for interaction studies.
• Chemical Biology Tool: Provides a photoactivatable (via the nitrophenyl group) and click-compatible handle for probing biological systems in live cells or complex mixtures.

Basic Information

Product Name	(4-Azido-2-Nitrophenyl)-5-Acetamido-2,3,5-Trideoxy-2-Thioglycerogalacto-2-Nonulopyranosidonic Acid
CAS No.	117681-72-8
Molecular Formula	C22H28N6O12S
Molecular Weight	600.56 g/mol
Synonyms	ANP-Sialic Acid; 5-Acetamido-2,3,5-trideoxy-2-thio-D-glycero-D-galacto-non-2-ulopyranosidonic acid, 9-(4-azido-2-nitrophenyl) derivative; 4-Azido-2-nitrophenyl α-thioketoside of N-acetylneuraminic acid; ANP-α-Sialic Acid; Sialic Acid-ANP conjugate; N-Acetylneuraminic acid ANP derivative; Glycoconjugate reagent 117681-72-8; Click chemistry sialic acid reagent
EINECS	Contact for details

Quality Control

Our production of (4-Azido-2-Nitrophenyl)-5-Acetamido-2,3,5-Trideoxy-2-Thioglycerogalacto-2-Nonulopyranosidonic Acid adheres to stringent quality protocols suitable for research and development applications. Each batch is characterized and tested to ensure high purity and structural integrity. A comprehensive Certificate of Analysis (COA) is provided, detailing results from HPLC, NMR, and mass spectrometry analyses. We support traceability and consistency for critical bioconjugation workflows.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This compound is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. Store away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to orange amorphous solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.