Description

4'-Demethyldehydropodophyllotoxin is a key lignan derivative and a significant intermediate in the synthesis of potent anticancer agents. This compound matters for its role as a crucial precursor in the development of novel chemotherapeutic drugs, particularly etoposide and teniposide analogs. Pharmaceutical research and development laboratories, as well as fine chemical manufacturers, require this high-purity intermediate for advanced drug discovery and production.

Application

• Pharmaceutical Intermediate: Primary building block for the semi-synthesis of podophyllotoxin-derived anticancer drugs like etoposide and teniposide.
• Medicinal Chemistry Research: Core scaffold for developing new cytotoxic agents targeting topoisomerase II.
• Biochemical Tool Compound: Used in in-vitro studies to investigate cell cycle arrest and apoptosis mechanisms.
• Reference Standard: Serves as a high-purity analytical standard for quality control in pharmaceutical manufacturing.
• Natural Product Synthesis: Intermediate in the total synthesis of complex lignan natural products.

Basic Information

Product Name	4'-Demethyldehydropodophyllotoxin
CAS No.	117669-31-5
Molecular Formula	C₂₁H₁₈O₇
Molecular Weight	382.36 g/mol
Synonyms	4'-Demethyl-dehydropodophyllotoxin; 4'-Desmethyldehydropodophyllotoxin; NSC 348948; 5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one; Dehydro-4'-demethylpodophyllotoxin; 4'-DDHP
EINECS	Contact for details

Quality Control

Our 4'-Demethyldehydropodophyllotoxin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.