Description

1H-1,2,3-Triazole-1-Carboxylic Acid, Methyl Ester (9Ci) is a versatile heterocyclic building block and key synthetic intermediate, primarily valued for its role in click chemistry and the construction of complex molecular architectures. Its significance lies in enabling efficient, high-yield reactions, such as Huisgen cycloadditions, which are critical for developing pharmaceuticals, agrochemicals, and advanced materials. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, crop protection, and specialty chemical industries seeking reliable, high-purity intermediates for innovative synthesis.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for triazole-containing drugs with antiviral, antifungal, or anticancer properties.
• Agrochemical Synthesis: Used in the development of novel fungicides, herbicides, and plant growth regulators that incorporate the 1,2,3-triazole moiety for enhanced bioactivity.
• Click Chemistry Reagent: Serves as a key component in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation, polymer functionalization, and material science applications.
• Ligand and Catalyst Development: Employed in the preparation of nitrogen-donor ligands for transition metal catalysis and organocatalysts.
• Polymer and Material Science: Acts as a monomer or cross-linking agent for creating functional polymers, coatings, and advanced materials with specific thermal or chemical properties.
• Research & Development: A valuable tool for medicinal chemistry and chemical biology research in academia and industry for library synthesis and probe development.

Basic Information

Product Name	1H-1,2,3-Triazole-1-Carboxylic Acid, Methyl Ester (9Ci)
CAS No.	117632-76-5
Molecular Formula	C4H5N3O2
Molecular Weight	127.10 g/mol
Synonyms	Methyl 1H-1,2,3-triazole-1-carboxylate; 1-Carbomethoxy-1,2,3-triazole; Methyl triazole-1-carboxylate; 1,2,3-Triazole-1-carboxylic acid methyl ester; 1H-1,2,3-Triazole-1-carboxylic acid, methyl ester; Triazole-1-carboxylic acid methyl ester; 1-Methoxycarbonyl-1,2,3-triazole
EINECS	Contact for details

Quality Control

Our 1H-1,2,3-Triazole-1-Carboxylic Acid, Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications requiring reliable and reproducible performance in critical synthetic pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound may be moisture-sensitive; keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.