Description

3-(2-Trifluoromethyl-Benzyloxy)-Pyridin-2-Ylamine is a high-value, fluorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique molecular structure, featuring a trifluoromethyl-benzyloxy moiety, makes it an essential intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: Key synthon for the research and development of new drug candidates, particularly in areas like kinase inhibitors and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group imparts improved lipophilicity and target binding.
• Material Science Research: Serves as a precursor for synthesizing specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a building block for creating molecular probes and activity-based protein profiling (ABPP) reagents.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes under cGMP conditions.

Basic Information

Item	Detail
Product Name	3-(2-Trifluoromethyl-Benzyloxy)-Pyridin-2-Ylamine
CAS No.	117523-95-2
Molecular Formula	C13H11F3N2O
Molecular Weight	268.24 g/mol
Synonyms	2-Amino-3-[(2-(trifluoromethyl)phenyl)methoxy]pyridine; 3-[(2-(Trifluoromethyl)benzyl)oxy]pyridin-2-amine; 2-Pyridinamine, 3-[[[2-(trifluoromethyl)phenyl]methyl]oxy]-; 3-(2-Trifluoromethyl-benzyloxy)-2-aminopyridine; 3-(α,α,α-Trifluoro-o-tolyloxy)-2-aminopyridine; 117523-95-2; 3-(2-(Trifluoromethyl)benzyloxy)pyridin-2-amine
EINECS	Contact for details

Quality Control

Every batch of 3-(2-Trifluoromethyl-Benzyloxy)-Pyridin-2-Ylamine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS is supplied with each shipment. Our quality protocols are designed to support regulatory filings in pharmaceutical and agrochemical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.