Description

Methyl 4-Chloro-4,4-Difluoroacetoacetate is a versatile fluorinated building block essential for introducing the difluoromethyl group into complex molecular architectures. This compound matters because it serves as a key intermediate in the synthesis of advanced agrochemicals and pharmaceuticals, enabling the creation of molecules with enhanced metabolic stability and bioavailability. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries.

Application

• Pharmaceutical Intermediate: A critical synthon for the preparation of difluoromethyl-containing active pharmaceutical ingredients (APIs), particularly in antiviral and anticancer drug discovery.
• Agrochemical Synthesis: Used in the manufacture of novel herbicides and pesticides, where the difluoromethyl group can improve efficacy and environmental profile.
• Fluorinated Material Precursor: Serves as a starting material for synthesizing specialty fluorinated polymers and liquid crystals with unique properties.
• Organic Synthesis Reagent: Employed in nucleophilic substitution and condensation reactions to construct complex, fluorinated heterocycles and aliphatic chains.
• Chemical Research & Development: A valuable tool for medicinal and process chemistry research to explore structure-activity relationships and develop new synthetic routes.

Basic Information

Product Name	Methyl 4-Chloro-4,4-Difluoroacetoacetate
CAS No.	117510-94-8
Molecular Formula	C5H5ClF2O3
Molecular Weight	186.54 g/mol
Synonyms	Methyl 4-Chloro-4,4-difluoro-3-oxobutanoate; 4-Chloro-4,4-difluoroacetoacetic Acid Methyl Ester; Methyl 4-Chloro-4,4-difluoro-3-oxobutyrate; 3-Oxobutanoic acid, 4-chloro-4,4-difluoro-, methyl ester; Methyl (4-chloro-4,4-difluoro-3-oxobutanoate); 117510-94-8; Methyl 4-chloro-4,4-difluoroacetoacetate
EINECS	Contact for details

Quality Control

Our Methyl 4-Chloro-4,4-Difluoroacetoacetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and sources of ignition. Due to its reactivity profile, it should be handled and stored separately from incompatible materials such as fluorides and strong alkalis.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.