Description

(4S,5S)-2,2,5-Trimethyl-1,3-Dioxolane-4-Carboxylic Acid Methyl Ester is a high-value chiral building block and synthetic intermediate of significant importance in asymmetric synthesis. This compound is prized for its ability to impart stereochemical control in the construction of complex molecules, ensuring high enantiomeric purity in the final products. It is primarily needed by pharmaceutical R&D and fine chemical manufacturers for the production of active pharmaceutical ingredients (APIs), agrochemicals, and specialty chemicals.

Application

• Pharmaceutical Synthesis: A key chiral intermediate in the production of enantiomerically pure drugs, particularly in antiviral and cardiovascular therapeutic areas.
• Agrochemical Manufacturing: Used in the synthesis of advanced, stereospecific pesticides and herbicides for enhanced efficacy.
• Fine Chemical Production: Serves as a versatile precursor for fragrances, flavors, and other high-value specialty chemicals requiring specific chirality.
• Academic & Industrial Research: Employed in methodological development and scale-up studies for novel asymmetric catalytic processes.
• Catalyst Ligand Preparation: Can be utilized in the synthesis of chiral ligands for asymmetric catalysis.

Basic Information

Product Name	(4S,5S)-2,2,5-Trimethyl-1,3-Dioxolane-4-Carboxylic Acid Methyl Ester
CAS No.	117181-61-0
Molecular Formula	C9H16O4
Molecular Weight	188.22 g/mol
Synonyms	(4S,5S)-2,2,5-Trimethyl-1,3-dioxolane-4-carboxylic acid methyl ester; Methyl (4S,5S)-2,2,5-trimethyl-1,3-dioxolane-4-carboxylate; (4S-cis)-2,2,5-Trimethyl-1,3-dioxolane-4-carboxylic Acid Methyl Ester; L-Threitol 1,4-Acetonide Methyl Ester; (4S,5S)-2,2,5-Trimethyl-4-(methoxycarbonyl)-1,3-dioxolane
EINECS	Contact for details

Quality Control

Our (4S,5S)-2,2,5-Trimethyl-1,3-Dioxolane-4-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. Certificates of Analysis (COA) with full specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.