Description

Cyclopropanecarboxylic Acid, 2-Acetyl-, Methyl Ester, (1S-Cis)- (9Ci) is a high-purity chiral building block and synthetic intermediate of significant interest in advanced organic synthesis. Its value lies in its unique cyclopropane ring structure and defined stereochemistry, which are critical for imparting specific biological activity and conformational rigidity in target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly where precise three-dimensional structure is required for efficacy.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the synthesis of advanced pesticides and herbicides, where the cyclopropane moiety can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Production: Employed in the multistep synthesis of complex natural products, flavors, and fragrances.
• Material Science Research: Investigated as a monomer or cross-linking agent for creating polymers with unique thermal and mechanical properties.
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry, particularly in cyclopropanation and stereoselective transformations.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 2-Acetyl-, Methyl Ester, (1S-Cis)- (9Ci)
CAS No.	116949-58-7
Molecular Formula	C8H12O3
Molecular Weight	156.18 g/mol
Synonyms	(1S-cis)-2-Acetylcyclopropanecarboxylic acid methyl ester; Methyl (1S,2S)-2-acetylcyclopropanecarboxylate; (1S,2S)-2-Acetylcyclopropanecarboxylic acid methyl ester; (-)-Methyl (1S,2S)-2-acetylcyclopropanecarboxylate; (1S,2S)-Methyl 2-acetylcyclopropanecarboxylate; 2-Acetylcyclopropanecarboxylic acid methyl ester, (1S-cis)-; (1S,2S)-2-Acetyl-1-cyclopropanecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxylic Acid, 2-Acetyl-, Methyl Ester, (1S-Cis)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC/GC), enantiomeric excess, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The container should be kept tightly sealed when not in use to prevent moisture absorption or contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.