Description

2-Hydroxy-4-Methyl-6-Trifluoromethyl-Nicotinnitrile is a high-value, fluorinated pyridine derivative that serves as a critical synthetic intermediate. Its core value lies in its unique trifluoromethyl and nitrile functional groups, which are instrumental in modulating the physicochemical and biological properties of target molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and biological activity.
• Material Science Research: Serves as a precursor for developing specialty chemicals, liquid crystals, or advanced polymers with specific electronic or surface properties.
• Chemical Biology Probe Development: Utilized in creating molecular probes and tool compounds for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Hydroxy-4-Methyl-6-Trifluoromethyl-Nicotinnitrile
CAS No.	116548-08-4
Molecular Formula	C8H5F3N2O
Molecular Weight	202.14 g/mol
Synonyms	6-(Trifluoromethyl)-2-hydroxy-4-methylnicotinonitrile; 2-Hydroxy-4-methyl-6-(trifluoromethyl)nicotinonitrile; 4-Methyl-6-(trifluoromethyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile; 2-Hydroxy-4-methyl-6-trifluoromethyl-3-cyanopyridine; 3-Cyano-4-methyl-6-trifluoromethyl-2-pyridone; 2-Pyridone, 3-cyano-4-methyl-6-(trifluoromethyl)-; 116548-08-4
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-4-Methyl-6-Trifluoromethyl-Nicotinnitrile is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our standard is to supply material with a typical purity of ≥97% (HPLC), with higher grades available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.