Description

1,2-Dihydro-2-Oxo-6-(Trifluoromethyl)-3-Pyridinecarboxylic Acid Ethyl Ester is a high-value fluorinated pyridine derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in the trifluoromethyl group, which imparts unique physicochemical properties essential for developing compounds with enhanced metabolic stability and bioavailability. This product is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group can improve lipophilicity and biological activity.
• Material Science Research: Serves as a precursor for novel fluorinated organic materials, including liquid crystals and polymers with specific electronic or surface properties.
• Chemical Biology & Probe Development: Employed in creating molecular probes and tags for studying biological processes, leveraging its fluorine atoms for potential use in 19F NMR spectroscopy.
• Custom Synthesis & Contract Manufacturing: A vital starting material for fine chemical manufacturers and CDMOs (Contract Development and Manufacturing Organizations) producing custom fluorinated compounds for clients.

Basic Information

Product Name	1,2-Dihydro-2-Oxo-6-(Trifluoromethyl)-3-Pyridinecarboxylic Acid Ethyl Ester
CAS No.	116548-02-8
Molecular Formula	C9H8F3NO3
Molecular Weight	235.16 g/mol
Synonyms	Ethyl 2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxylate; 6-(Trifluoromethyl)-2-oxo-1,2-dihydropyridine-3-carboxylic Acid Ethyl Ester; 2-Oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxylic Acid Ethyl Ester; 3-Pyridinecarboxylic acid, 1,2-dihydro-2-oxo-6-(trifluoromethyl)-, ethyl ester; Ethyl 6-(trifluoromethyl)-2-oxo-1,2-dihydronicotinate
EINECS	Contact for details

Quality Control

Our 1,2-Dihydro-2-Oxo-6-(Trifluoromethyl)-3-Pyridinecarboxylic Acid Ethyl Ester is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.