Description

3-(tert-Butyldimethylsiloxy)Butyric Acid Methyl Ester is a versatile organosilicon-protected intermediate of significant value in advanced organic synthesis. This compound is crucial for its role in the controlled introduction and protection of functional groups, enabling the synthesis of complex molecules with high precision. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for the development of active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for protecting hydroxyl groups during complex reaction sequences.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and plant growth regulators requiring specific stereochemistry.
• Peptide Chemistry: Serves as a protected synthon in the synthesis of peptide analogs and other biologically active compounds.
• Material Science Research: Employed in the development of novel polymers, liquid crystals, and organic electronic materials where precise molecular architecture is required.
• Asymmetric Synthesis: Acts as a chiral precursor or auxiliary in catalytic asymmetric reactions to produce enantiomerically pure compounds.
• Cross-Coupling Reactions: Functions as a substrate in palladium-catalyzed and other metal-mediated coupling reactions to form carbon-carbon bonds.

Basic Information

Product Name	3-(tert-Butyldimethylsiloxy)Butyric Acid Methyl Ester
CAS No.	116414-91-6
Molecular Formula	C11H24O3Si
Molecular Weight	232.40 g/mol
Synonyms	Methyl 3-[(tert-Butyldimethylsilyl)oxy]butanoate; Methyl 3-(tert-Butyldimethylsiloxy)butyrate; 3-(TBDMSO)Butyric Acid Methyl Ester; 3-[(tert-Butyldimethylsilyl)oxy]butanoic Acid Methyl Ester; 3-(tert-Butyldimethylsilyloxy)butyric Acid Methyl Ester; Butanoic acid, 3-[(1,1-dimethylethyl)dimethylsilyl]oxy]-, methyl ester; TBDMS-protected 3-hydroxybutyrate methyl ester
EINECS	Contact for details

Quality Control

Our production of 3-(tert-Butyldimethylsiloxy)Butyric Acid Methyl Ester adheres to stringent in-process controls to ensure batch-to-batch consistency and high chemical purity. We employ advanced analytical techniques, including GC, HPLC, and NMR, to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, and custom purity grades to meet specific research or cGMP starting material requirements are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.