Description

L-Alanine, n-2-Propynyl-, Methyl Ester (9Ci) CAS NO 116366-79-1 is a specialized alanine derivative characterized by a propargyl (2-propynyl) substitution and a methyl ester functional group. This unique molecular architecture makes it a valuable chiral building block and intermediate in advanced organic synthesis, particularly for constructing complex molecules with specific stereochemistry. It is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced material sectors who require high-purity, structurally defined intermediates for drug discovery, peptide mimetics, and ligand synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for introducing the alanine backbone with a propargyl handle for further functionalization via click chemistry.
• Peptidomimetics & Bio-conjugation: Used in the synthesis of modified peptides and peptidomimetics where the propargyl group enables site-specific labeling or cross-linking with azide-containing molecules.
• Agrochemical Research: Acts as a building block for novel herbicides, fungicides, or plant growth regulators that incorporate amino acid motifs for enhanced bioavailability or target specificity.
• Chemical Biology Probes: Employed in creating activity-based probes and molecular tools for studying enzyme function and protein-protein interactions within biological systems.
• Ligand Synthesis for Catalysis: Utilized in the preparation of chiral ligands for asymmetric catalysis, contributing to more efficient and selective synthetic routes.
• Material Science Research: Functions as a monomer or precursor for novel polymers and smart materials with tailored properties derived from its amino acid and alkyne functionality.

Basic Information

Product Name	L-Alanine, n-2-Propynyl-, Methyl Ester (9Ci)
CAS No.	116366-79-1
Molecular Formula	C7H11NO2
Molecular Weight	141.17 g/mol
Synonyms	Methyl (2S)-2-(prop-2-yn-1-ylamino)propanoate; L-Alanine, N-2-propynyl-, methyl ester; Methyl N-(prop-2-yn-1-yl)-L-alaninate; (S)-Methyl 2-(prop-2-yn-1-ylamino)propanoate; N-Propargyl-L-alanine methyl ester; Propargyl-L-alanine methyl ester; Alanine, N-2-propynyl-, methyl ester, L-; Methyl N-propargyl-L-alaninate
EINECS	Contact for details

Quality Control

Our L-Alanine, n-2-Propynyl-, Methyl Ester (9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.