Description

Methyl 2-(5-Fluoro-2-Nitrophenoxy)Acetate is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. This compound matters because its unique structure, featuring both a nitro and a fluoro substituent on the phenoxy ring, makes it a versatile precursor for constructing complex molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the fluoronitrophenoxy moiety imparts specific biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for advanced electronic materials requiring fluorinated aromatic components for optimal performance.
• Dye & Pigment Intermediate: Employed in the synthesis of specialized dyes and pigments where the nitro group facilitates further chemical transformations.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl structures.
• Academic & Contract Research: A valuable reagent for methodological development and discovery chemistry in academic and contract research organizations (CROs).

Basic Information

Product Name	Methyl 2-(5-Fluoro-2-Nitrophenoxy)Acetate
CAS No.	116355-65-8
Molecular Formula	C9H8FNO5
Molecular Weight	229.16 g/mol
Synonyms	Acetic acid, 2-(5-fluoro-2-nitrophenoxy)-, methyl ester; Methyl (5-fluoro-2-nitrophenoxy)acetate; 2-(5-Fluoro-2-nitrophenoxy)acetic acid methyl ester; Methyl 5-fluoro-2-nitrophenoxyacetate; Methyl α-(5-fluoro-2-nitrophenoxy)acetate; 5-Fluoro-2-nitrophenoxyacetic acid methyl ester; Methyl (5-fluoro-2-nitro-phenoxy)acetate
EINECS	Contact for details

Quality Control

Our Methyl 2-(5-Fluoro-2-Nitrophenoxy)Acetate is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support cGMP compliance for pharmaceutical applications and can tailor quality documentation to meet specific regulatory or client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.