Description

tert-Butyl ((1R,2S)-2-(4-Nitrophenyl)cyclopropyl)carbamate is a high-purity chiral building block and advanced pharmaceutical intermediate of significant commercial importance. Its defined stereochemistry and functionalized cyclopropane ring make it a critical precursor in the synthesis of complex, biologically active molecules. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to explore new chemical entities.
• Process Chemistry Development: Serves as a critical starting material or intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Asymmetric Synthesis: Utilized in the construction of complex molecules requiring the specific (1R,2S) stereochemistry of the cyclopropane moiety.
• Protease Inhibitor Research: The structural motif is relevant in the development of inhibitors for various enzymatic targets.
• Chemical Biology: Can be employed as a molecular scaffold or probe in biochemical studies.

Basic Information

Product Name	tert-Butyl ((1R,2S)-2-(4-Nitrophenyl)cyclopropyl)carbamate
CAS No.	115977-41-8
Molecular Formula	C14H18N2O4
Molecular Weight	278.31 g/mol
Synonyms	(1R,2S)-2-(4-Nitrophenyl)cyclopropanaminium, N-Boc-; tert-Butyl N-[(1R,2S)-2-(4-nitrophenyl)cyclopropyl]carbamate; BOC-(1R,2S)-2-(4-Nitrophenyl)cyclopropylamine; (1R,2S)-N-Boc-2-(4-nitrophenyl)cyclopropylamine; (1R,2S)-2-(p-Nitrophenyl)cyclopropylcarbamic acid tert-butyl ester; tert-Butoxycarbonyl-(1R,2S)-2-(4-nitrophenyl)cyclopropylamine; BOC-ACP; ACP-BOC
EINECS	Contact for details

Quality Control

Our tert-Butyl ((1R,2S)-2-(4-Nitrophenyl)cyclopropyl)carbamate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing critical parameters such as chiral purity, chemical purity, and identity confirmation. We adhere to ISO 9001 quality management principles, and our processes are designed to meet the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound is moisture-sensitive (hygroscopic) and should be handled under inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% de (for (1R,2S) isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.