Description

Dimethyl Bicyclo[1.1.1]pentane-1,3-dicarboxylate is a high-value, strained bicyclic organic compound that serves as a critical synthetic building block. Its unique [1.1.1]propellane-derived structure makes it an essential precursor for the synthesis of rigid, linear linkers and advanced pharmaceutical intermediates. This product is primarily sought by research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor for synthesizing bioisosteres, particularly for replacing phenyl or other aromatic rings to modulate drug properties like solubility, metabolic stability, and three-dimensional shape.
• Agrochemical Synthesis: Used in the research and development of novel active ingredients requiring rigid, linear structural components.
• Materials Science: Building block for creating rigid organic linkers in Metal-Organic Frameworks (MOFs), covalent organic frameworks (COFs), and polymers with specific mechanical or electronic properties.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Employed as a non-traditional linker to connect E3 ligase ligands to target protein ligands, enhancing cellular permeability and degradation efficiency.
• Academic & Industrial R&D: Fundamental reagent for methodological development in organic synthesis and exploration of strained hydrocarbon chemistry.

Basic Information

Product Name	Dimethyl Bicyclo[1.1.1]pentane-1,3-dicarboxylate
CAS No.	115913-32-1
Molecular Formula	C9H12O4
Molecular Weight	184.19 g/mol
Synonyms	1,3-Bicyclo[1.1.1]pentanedicarboxylic acid dimethyl ester; Dimethyl 1,3-bicyclo[1.1.1]pentanedicarboxylate; Dimethyl [1.1.1]propellane-1,3-dicarboxylate; Methyl bicyclo[1.1.1]pentane-1,3-dicarboxylate; BCP-DME; [1.1.1]Propellane-1,3-dicarboxylic acid dimethyl ester
EINECS	Contact for details

Quality Control

Our Dimethyl Bicyclo[1.1.1]pentane-1,3-dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.