Description

4-(2-Iodo-Phenyl)-3-Oxo-Butyric Acid Methyl Ester is a versatile and high-purity organic building block essential for advanced chemical synthesis. This compound is valued for its reactive β-keto ester functionality and the presence of an iodine substituent, making it a critical intermediate in the development of complex molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its modifiable functional groups.
• Organic Synthesis: Serves as a precursor for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) enabled by the aryl iodide moiety.
• Chemical Development: Employed in process chemistry for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Agrochemical Research: Potential intermediate in the development of novel crop protection agents and herbicides.
• Material Science: Can be utilized in the synthesis of specialized organic compounds for advanced materials.

Basic Information

Product Name	4-(2-Iodo-Phenyl)-3-Oxo-Butyric Acid Methyl Ester
CAS No.	115860-27-0
Molecular Formula	C11H11IO3
Molecular Weight	318.11 g/mol
Synonyms	Methyl 4-(2-iodophenyl)-3-oxobutanoate; 3-Oxobutanoic acid, 4-(2-iodophenyl)-, methyl ester; Methyl 3-oxo-4-(2-iodophenyl)butanoate; 4-(2-Iodophenyl)-3-oxobutyric acid methyl ester; 2-Iodobenzylacetone methyl ester; 4-(o-Iodophenyl)-3-oxobutanoic acid methyl ester; β-Keto ester intermediate 115860-27-0
EINECS	Contact for details

Quality Control

Our 4-(2-Iodo-Phenyl)-3-Oxo-Butyric Acid Methyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) is supplied with every batch, detailing all relevant specifications. Our quality system is designed to support cGMP and ISO standards for reliable sourcing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.