Description

1-Bromo-2-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-benzene is a specialized organosilicon-protected phenolic intermediate of significant value in advanced organic synthesis. This compound matters because it provides a robust and versatile protecting group for phenolic hydroxyl functions, enabling selective reactions in complex multi-step syntheses. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly where phenol protection is required.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides that contain halogenated phenolic structures.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the creation of novel monomers and polymers with specific silicon-containing backbones for specialty materials.
• Organic Synthesis Reagent: A versatile reagent for introducing the tert-butyldimethylsilyl (TBDMS) protecting group onto phenolic substrates under mild conditions.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for biaryl formation.

Basic Information

Product Name	1-Bromo-2-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-benzene
CAS No.	115750-83-9
Molecular Formula	C12H19BrOSi
Molecular Weight	287.27 g/mol
Synonyms	2-Bromophenyl tert-butyldimethylsilyl ether; 2-Bromo-1-[(tert-butyldimethylsilyl)oxy]benzene; 1-Bromo-2-[(tert-butyldimethylsilyl)oxy]benzene; o-Bromophenol TBDMS ether; 2-Bromophenoxy-tert-butyldimethylsilane; TBDMS ether of 2-bromophenol; (2-Bromophenoxy)(tert-butyl)dimethylsilane; 2-Bromo-1-((tert-butyldimethylsilyl)oxy)benzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-benzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data, including HPLC, GC, and NMR characterization, to verify identity and purity. Certificates of Analysis (COA) are available upon request for every batch, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.