Description

(S)-(+)-Nipecotic Acid Ethyl Ester Hcl is a high-purity, enantiomerically pure chiral building block and intermediate of significant importance in pharmaceutical research and development. This compound is valued for its role as a precursor in the synthesis of GABA (γ-aminobutyric acid) analogs and other bioactive molecules targeting the central nervous system. It is primarily needed by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the development of new therapeutic agents, particularly for neurological disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potent GABA uptake inhibitors and receptor modulators.
• Neurological Research: Used as a building block for creating novel ligands to study GABAergic neurotransmission and related pathways.
• Medicinal Chemistry: Serves as a critical starting material for structure-activity relationship (SAR) studies in drug discovery programs.
• Asymmetric Synthesis: Employed in chiral pool synthesis due to its defined (S)-(+) configuration to impart stereochemistry into target molecules.
• Reference Standard: Utilized as an analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	(S)-(+)-Nipecotic Acid Ethyl Ester Hcl
CAS No.	115655-08-8
Molecular Formula	C8H15NO2 • HCl
Molecular Weight	193.67 (Free base) / 230.12 (HCl salt)
Synonyms	(S)-(+)-Nipecotic Acid Ethyl Ester Hydrochloride; Ethyl (S)-3-Piperidinecarboxylate Hydrochloride; (S)-1,2,3,6-Tetrahydropyridine-3-carboxylic Acid Ethyl Ester Hydrochloride; (S)-Nipecotic Acid Ethyl Ester HCl; (S)-Ethyl Nipecotate Hydrochloride; (3S)-3-Piperidinecarboxylic Acid Ethyl Ester Hydrochloride; (S)-3-Carbethoxypiperidine Hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-(+)-Nipecotic Acid Ethyl Ester Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-grade standards suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.