Description

Methyl (2S)-2-Amino-3-[(Triphenylmethyl)Sulfanyl]Propanoate CAS NO 115545-85-2 is a high-purity, chiral amino acid derivative featuring a trityl-protected thiol group. This compound is a critical building block in the synthesis of complex peptides and other biologically active molecules, where precise stereochemistry and protecting group strategies are paramount. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of cysteine-containing peptides and peptidomimetics with therapeutic potential.
• Peptide Synthesis: Serves as a protected cysteine derivative in solid-phase and solution-phase peptide synthesis (SPPS), enabling the controlled introduction of thiol functionality.
• Chemical Biology Research: Used in the development of enzyme inhibitors, protein probes, and other tools where a protected thiol handle is required for further conjugation.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) requiring high enantiomeric purity.
• Ligand and Catalyst Development: Acts as a precursor for chiral ligands used in asymmetric catalysis.

Basic Information

Product Name	Methyl (2S)-2-Amino-3-[(Triphenylmethyl)Sulfanyl]Propanoate
CAS No.	115545-85-2
Molecular Formula	C23H23NO2S
Molecular Weight	377.50 g/mol
Synonyms	Methyl L-Cysteine(Trt)-OH; (S)-Methyl 2-amino-3-(tritylthio)propanoate; L-Cysteine, methyl ester, N-trityl derivative; Methyl (S)-2-amino-3-(tritylthio)propanoate; Methyl N-trityl-L-cysteinate; 115545-85-2; Trt-Cys-OMe; Fmoc-Cys(Trt)-OH methyl ester analog
EINECS	Contact for details

Quality Control

Our Methyl (2S)-2-Amino-3-[(Triphenylmethyl)Sulfanyl]Propanoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.