Description

Fmoc-Cys(Trt)-Opfp CAS NO 115520-21-3 is a specialized, high-purity amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block, offering orthogonal protection for the cysteine side chain with the Trt (trityl) group and an activated pentafluorophenyl (Opfp) ester for efficient coupling. It is essential for researchers and manufacturers requiring precise, high-yield incorporation of cysteine residues under standard Fmoc-chemistry conditions. This reagent is primarily utilized in pharmaceutical R&D, biotechnology, and academic laboratories for the synthesis of complex peptides, including therapeutic candidates and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key monomer for the automated or manual synthesis of peptide chains using Fmoc/t-Bu chemistry.
• Pharmaceutical Research & Development: For constructing peptide-based drug candidates, hormones, and enzyme inhibitors where cysteine is a critical residue.
• Bioconjugation and Labeling: Enables the site-specific introduction of cysteine, which can later be used for conjugation with labels, tags, or other molecules via its thiol group.
• Synthesis of Disulfide-Rich Peptides: Facilitates the controlled formation of disulfide bonds, which are crucial for the structure and activity of many bioactive peptides.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive peptide sequences.
• Production of Custom Peptides: For contract research organizations (CROs) and CDMOs supplying research-grade and GMP-grade peptides.

Basic Information

Product Name	Fmoc-Cys(Trt)-Opfp
CAS No.	115520-21-3
Molecular Formula	C43H32F5NO4S
Molecular Weight	753.78 g/mol
Synonyms	Fmoc-Cys(Trt)-OPfp; Fmoc-S-trityl-L-cysteine pentafluorophenyl ester; N-(9-Fluorenylmethoxycarbonyl)-S-trityl-L-cysteine pentafluorophenyl ester; Fmoc-Cysteine(Trt)-Opfp ester; Fmoc-L-Cys(Trt)-OPfp; Nα-Fmoc-S-trityl-L-cysteine pentafluorophenyl ester; (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-tritylsulfanyl-propanoic acid 2,3,4,5,6-pentafluorophenyl ester; Fmoc-Cys(Trt)-O-Pfp
EINECS	Contact for details

Quality Control

Our Fmoc-Cys(Trt)-Opfp is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support compliance with relevant guidelines for pharmaceutical ingredient sourcing.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	-15.0° to -25.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.