Description

6-Chloronicotinic Acid tert-Butyl Ester is a high-purity chemical intermediate of significant importance in advanced organic synthesis. This compound matters because it serves as a versatile and protected building block for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and other fine chemicals where the introduction of a functionalized nicotinic acid moiety is required.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting the central nervous system or metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the bioactivity of the chloronicotinate scaffold.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials and functional polymers.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.
• Academic and Industrial R&D: A valuable reagent for methodological studies in organic chemistry and scale-up process optimization.

Basic Information

Product Name	6-Chloronicotinic Acid tert-Butyl Ester
CAS No.	115309-57-4
Molecular Formula	C10H12ClNO2
Molecular Weight	213.66 g/mol
Synonyms	tert-Butyl 6-chloropyridine-3-carboxylate; 6-Chloro-3-pyridinecarboxylic Acid 1,1-Dimethylethyl Ester; 6-Chloronicotinic Acid t-Butyl Ester; 3-Carboxy-6-chloropyridine tert-Butyl Ester; 6-Chloro-nicotinic acid tert-butyl ester; 6-Chloropyridine-3-carboxylic acid tert-butyl ester; t-Butyl 6-chloronicotinate
EINECS	Contact for details

Quality Control

Every batch of 6-Chloronicotinic Acid tert-Butyl Ester is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical control, including HPLC, GC, and NMR, is employed to guarantee identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specification results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.