Description

Tallimustine is a synthetic alkylating agent belonging to the nitrogen mustard class of compounds, known for its potent biological activity. This compound is of significant interest in pharmaceutical research and development due to its mechanism of action, which involves the formation of covalent bonds with DNA, leading to cell cycle arrest and apoptosis. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel chemotherapeutic agents and targeted cancer therapies. Tallimustine CAS NO 115308-98-0 represents a key intermediate and reference standard for advanced oncological studies.

Application

• Pharmaceutical Research: Serves as a critical reference standard and active pharmaceutical ingredient (API) in the development of new anticancer drugs.
• Biochemical Studies: Used as a tool compound to investigate DNA alkylation mechanisms, DNA repair pathways, and cellular responses to genotoxic stress.
• Preclinical Development: Employed in in vitro and in vivo models to evaluate efficacy, pharmacokinetics, and toxicology profiles of alkylating agent-based therapies.
• Oncology Target Validation: Acts as a positive control in assays designed to screen for compounds with similar or improved cytotoxic profiles.
• Academic Research: Utilized in university and institutional labs for fundamental studies in medicinal chemistry and molecular pharmacology.

Basic Information

Product Name	Tallimustine
CAS No.	115308-98-0
Molecular Formula	C19H24Cl2N4O4
Molecular Weight	443.32 g/mol
Synonyms	FCE 24517; Tallimustina; Tallimustinum; Benzenepropanamide, N-[2-[bis(2-chloroethyl)amino]-6-methoxy-9-acridinyl]-; N-[2-[Bis(2-chloroethyl)amino]-6-methoxy-9-acridinyl]benzenepropanamide; 9-Acridinamine, N-[2-[bis(2-chloroethyl)amino]-6-methoxy-9-acridinyl]benzenepropanamide deriv.
EINECS	Contact for details

Quality Control

Our Tallimustine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification by spectroscopic methods, purity assessment by HPLC, and control of specified impurities. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.