Description

3-Butynoicacid,2-Amino-2-Methyl-,Methylester,(R)-(9Ci) is a chiral, non-proteinogenic amino acid derivative characterized by its alkyne and ester functional groups, making it a versatile and valuable synthetic building block. This compound is essential for the development of novel pharmaceuticals and bioactive molecules, particularly in the creation of peptidomimetics and constrained peptide analogs. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of complex active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in oncology and metabolic disease research.
• Peptidomimetic Synthesis: Used to introduce conformational constraints and alkyne "click chemistry" handles into peptide backbones for drug discovery.
• Bioconjugation & Probe Development: The alkyne moiety enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) for labeling biomolecules and creating diagnostic probes.
• Asymmetric Synthesis: Serves as a chiral auxiliary or building block in stereoselective reactions to construct complex molecular architectures.
• Agrochemical Research: Employed in the research and development of new, more effective crop protection agents with specific modes of action.
• Material Science: A potential monomer for creating specialized polymers with unique mechanical or biological properties.

Basic Information

Product Name	3-Butynoicacid,2-Amino-2-Methyl-,Methylester,(R)-(9Ci)
CAS No.	115228-55-2
Molecular Formula	C7H11NO2
Molecular Weight	141.17 g/mol
Synonyms	(R)-Methyl 2-amino-2-methylbut-3-ynoate; (R)-2-Amino-2-methyl-3-butynoic acid methyl ester; Methyl (R)-2-amino-2-methylbut-3-ynoate; (R)-2-Amino-2-methyl-but-3-ynoic acid methyl ester; (R)-2-Amino-2-methyl-3-butynoate methyl ester; (R)-2-Methyl-2-aminobut-3-ynoic acid methyl ester; (R)-Amino-methylbutynoate
EINECS	Contact for details

Quality Control

Our 3-Butynoicacid,2-Amino-2-Methyl-,Methylester,(R)-(9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting research and pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.