Description

Proline, 4-Hydroxy-5-Oxo-, Ethyl Ester, trans- (9Ci) is a specialized proline derivative, a key chiral synthon and protected amino acid building block for advanced organic synthesis. Its value lies in providing a functionalized, enantiomerically pure scaffold that is critical for constructing complex molecules with high stereochemical fidelity. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, as well as in academic settings for methodological studies in asymmetric synthesis.

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis of protease inhibitors, antiviral agents, and other bioactive molecules requiring specific stereochemistry.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and plant growth regulators that utilize amino acid motifs.
• Peptidomimetics & Drug Discovery: Serves as a constrained proline analog for creating peptide mimics to enhance metabolic stability and receptor selectivity in drug candidates.
• Asymmetric Catalysis Ligand Precursor: Acts as a starting material for synthesizing novel chiral ligands and organocatalysts used in enantioselective transformations.
• Fine Chemical & Specialty Chemical Production: Employed in custom synthesis and contract manufacturing of high-value, complex organic compounds.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry, particularly in studies involving amino acid functionalization and heterocycle formation.

Basic Information

Item	Detail
Product Name	Proline, 4-Hydroxy-5-Oxo-, Ethyl Ester, trans- (9Ci)
CAS No.	115223-52-4
Molecular Formula	C8H11NO4
Molecular Weight	185.18 g/mol
Synonyms	trans-4-Hydroxy-5-oxoproline ethyl ester; Ethyl (2S,4R)-4-hydroxy-5-oxopyrrolidine-2-carboxylate; Ethyl 4-hydroxy-5-oxo-L-prolinate; L-Proline, 4-hydroxy-5-oxo-, ethyl ester, (4R)-; 4-Hydroxy-5-oxoproline ethyl ester; 5-Oxo-4-hydroxyproline ethyl ester; (4R)-4-Hydroxy-5-oxo-L-proline ethyl ester
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our fine chemical intermediates. Production follows cGMP principles where applicable, and every batch is analyzed to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications such as chiral purity (enantiomeric excess), chemical purity (by HPLC), and relevant physical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (ee)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.