Description

Dc-Me Phosphonamidite CAS NO 115147-72-3 is a specialized phosphoramidite monomer, a critical building block in the automated solid-phase synthesis of oligonucleotides. Its primary value lies in enabling the precise and efficient incorporation of modified nucleosides into DNA and RNA strands, which is essential for advanced research and therapeutic development. This high-purity reagent is indispensable for pharmaceutical R&D, biotechnology companies, and academic institutions focused on antisense therapeutics, siRNA, aptamers, and molecular diagnostics.

Application

• Oligonucleotide Synthesis: As a key phosphoramidite monomer for the solid-phase synthesis of modified DNA and RNA sequences.
• Therapeutic Oligonucleotide Development: Production of antisense oligonucleotides (ASOs), small interfering RNA (siRNA), and aptamers for targeted therapies.
• Diagnostic Probe Manufacturing: Creation of labeled probes and primers used in PCR, sequencing, and microarray technologies.
• Research & Development: Tool for chemical biology and medicinal chemistry research to study nucleic acid interactions and function.
• Synthesis of Modified Nucleosides: Introduction of specific functional groups or labels at precise locations within an oligonucleotide chain.

Basic Information

Product Name	Dc-Me Phosphonamidite
CAS No.	115147-72-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-N4-methylcytidine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; DMT-dC(Me) Phosphoramidite; N4-Methyl-2'-deoxycytidine phosphoramidite; 2'-Deoxy-N4-methylcytidine phosphoramidite; dC(Me) Phosphoramidite; N4-Methyldeoxycytidine CE Phosphoramidite
EINECS	Contact for details

Quality Control

Our Dc-Me Phosphonamidite is manufactured under strict quality-controlled conditions to ensure the high purity and consistency required for sensitive oligonucleotide synthesis. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content. We adhere to industry best practices and can support development under quality agreements for cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, moisture-free environment. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air or ambient temperature will compromise quality and reactivity.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC/LC-MS)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Moisture Content (Karl Fischer)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.