Description

D-Proline, 1-Methyl-, Methyl Ester (9Ci) is a chiral, non-proteinogenic amino acid derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a crucial chiral building block and intermediate for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking high-purity, stereochemically defined intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of complex drug molecules, particularly peptidomimetics and protease inhibitors.
• Agrochemical Research: Used in the development of novel chiral pesticides and herbicides where specific stereochemistry is required for biological activity.
• Catalyst & Ligand Synthesis: Serves as a precursor for the preparation of chiral catalysts and ligands used in asymmetric catalysis.
• Peptide Chemistry: Employed in the synthesis of modified peptides and peptoids to study structure-activity relationships (SAR).
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis and medicinal chemistry projects.

Basic Information

Product Name	D-Proline, 1-Methyl-, Methyl Ester (9Ci)
CAS No.	114883-82-8
Molecular Formula	C7H13NO2
Molecular Weight	143.18 g/mol
Synonyms	Methyl (2R)-1-methylpyrrolidine-2-carboxylate; (R)-1-Methylproline methyl ester; D-1-Methylproline methyl ester; Methyl (R)-1-methylpyrrolidine-2-carboxylate; (R)-1-Methyl-2-pyrrolidinecarboxylic acid methyl ester; (R)-1-Methylproline methyl ester hydrochloride (salt form); (2R)-1-Methylpyrrolidine-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our D-Proline, 1-Methyl-, Methyl Ester (9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.