Description

1,2-o-Isopropylidene-5-o-(T-Butyldiphenylsilyl)-α-D-Xylofuranose is a key protected carbohydrate intermediate, specifically a xylofuranose derivative with orthogonal protecting groups. This compound is critically important for its role in the precise and controlled synthesis of complex nucleoside analogs and other bioactive molecules. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers specializing in antiviral and anticancer drug development, where it serves as a sophisticated chiral building block.

Application

• Nucleoside Analog Synthesis: A crucial chiral precursor for the development of modified nucleosides used in antiviral and anticancer therapeutics.
• Pharmaceutical Intermediates: Serves as a high-value building block in multi-step organic synthesis for active pharmaceutical ingredients (APIs).
• Carbohydrate Chemistry Research: Used in academic and industrial laboratories to study glycosylation reactions and sugar moiety modifications.
• Oligonucleotide Synthesis: Employed in the preparation of modified sugar backbones for advanced oligonucleotide drugs and probes.
• Glycoconjugate Development: Acts as a protected intermediate in the synthesis of complex glycoconjugates for biological studies.
• Process Chemistry: Utilized in scale-up and optimization of synthetic routes for pharmaceutical candidates requiring specific stereochemistry.

Basic Information

Product Name	1,2-o-Isopropylidene-5-o-(T-Butyldiphenylsilyl)-α-D-Xylofuranose
CAS No.	114861-14-2
Molecular Formula	C24H32O5Si
Molecular Weight	428.60 g/mol
Synonyms	5-O-(tert-Butyldiphenylsilyl)-1,2-O-isopropylidene-α-D-xylofuranose; 1,2-O-Isopropylidene-5-O-(tert-butyldiphenylsilyl)-α-D-xylofuranose; 1,2-O-Isopropylidene-5-O-(TBDPS)-α-D-xylofuranose; α-D-Xylofuranose, 1,2-O-(1-methylethylidene)-5-O-[1,1-dimethylethyl(diphenyl)silyl]-; TBDPS-protected isopropylidene xylofuranose; 5-O-TBDPS-1,2-O-isopropylidene-α-D-xylofuranose
EINECS	Contact for details

Quality Control

Our 1,2-o-Isopropylidene-5-o-(T-Butyldiphenylsilyl)-α-D-Xylofuranose is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and process chemistry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container sealed under an inert atmosphere to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.