Description

(R)-Methyl 2-Hydroxy-2-((4R,4'R,5R)-2,2,2',2'-Tetramethyl-4,4'-Bi(1,3-Dioxolan)-5-Yl) Acetate is a high-value chiral building block and synthetic intermediate, distinguished by its precise stereochemistry and protected diol functionality. Its primary commercial value lies in enabling the asymmetric synthesis of complex molecules, particularly in the pharmaceutical sector where enantiomeric purity is critical. This compound is essential for research chemists and process development scientists working on active pharmaceutical ingredients (APIs), fine chemicals, and advanced material science.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially for antiviral, anticancer, and cardiovascular therapies.
• Asymmetric Synthesis: Serves as a precursor for introducing stereocenters in natural product synthesis and the preparation of enantiomerically pure compounds.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, advanced ligands, and catalysts for organic transformations.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and process chemistry optimization.
• Agrochemical Synthesis: Potential intermediate in the development of chiral pesticides and herbicides requiring specific biological activity.

Basic Information

Item	Details
Product Name	(R)-Methyl 2-Hydroxy-2-((4R,4'R,5R)-2,2,2',2'-Tetramethyl-4,4'-Bi(1,3-Dioxolan)-5-Yl) Acetate
CAS No.	114743-85-0
Molecular Formula	C15H26O7
Molecular Weight	318.36 g/mol
Synonyms	(R)-Methyl 2-Hydroxy-2-((4R,4'R,5R)-2,2,2',2'-Tetramethyl-4,4'-bi(1,3-dioxolan)-5-yl)acetate; Methyl (2R)-2-hydroxy-2-[(4R,4'R,5R)-2,2,2',2'-tetramethyl-4,4'-bi(1,3-dioxolan)-5-yl]acetate; (R)-Mandelic Acid Derivative; Chiral Acetonide Protected Mandelate Ester; (R,R,R)-Isomer of the Tetramethyl Bi(dioxolanyl) Acetate
EINECS	Contact for details

Quality Control

We supply (R)-Methyl 2-Hydroxy-2-((4R,4'R,5R)-2,2,2',2'-Tetramethyl-4,4'-Bi(1,3-Dioxolan)-5-Yl) Acetate with a strong commitment to enantiomeric purity and batch-to-batch consistency. Our products undergo rigorous quality testing, including chiral HPLC analysis, to ensure compliance with stringent research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess (ee), and identity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.