Description

L-Alanine, n-Methyl-, 1,1-Dimethylethyl Ester (9Ci) is a protected amino acid derivative, specifically a tert-butyl ester of N-methyl-L-alanine, with the CAS number 114525-98-3. This compound is a critical building block in organic synthesis, valued for its role in introducing the N-methyl alanine moiety while providing orthogonal protection strategies. It is primarily needed by pharmaceutical research and fine chemical synthesis teams for the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates and bioactive peptides.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate N-methylated amino acids, which can enhance metabolic stability and membrane permeability.
• Protease Inhibitor Development: Serves as a precursor in creating inhibitors for various enzymatic targets.
• Chemical Biology Research: Employed in the study of protein-protein interactions and the design of peptide-based probes.
• Agrochemical Synthesis: Potential intermediate in the production of specialized chiral agrochemicals.
• Material Science: Can be utilized in the synthesis of functionalized polymers and advanced materials.

Basic Information

Item	Detail
Product Name	L-Alanine, n-Methyl-, 1,1-Dimethylethyl Ester (9Ci)
CAS No.	114525-98-3
Molecular Formula	C8H17NO2
Molecular Weight	159.23 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)(methyl)amino)propanoic acid; N-Boc-N-methyl-L-alanine; Boc-N-Me-L-Ala-OH; tert-Butyl N-methyl-L-alaninate; N-Methyl-L-alanine tert-butyl ester; (S)-tert-Butyl 2-(methylamino)propanoate; Boc-N-methyl-L-alanine; L-Alanine, N-methyl-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our L-Alanine, n-Methyl-, 1,1-Dimethylethyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.