Description

Cyclopropanecarboxylic Acid, 1-Amino-2-(Hydroxymethyl)-, Methyl Ester, (1S- CAS NO 114498-10-1 is a high-purity, single-enantiomer chiral building block of significant interest in advanced organic synthesis. This compound matters for its unique cyclopropane ring fused with amino and hydroxymethyl functionalities, offering a rigid, three-dimensional scaffold for constructing complex molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, where its stereochemistry and functional groups are critical for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral therapies.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the cyclopropane moiety can enhance stability and bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics Research: The amino acid-like structure makes it valuable for creating constrained peptide analogs in medicinal chemistry.
• Chemical Biology Probes: Utilized in the design of molecular probes to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high stereochemical purity.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 1-Amino-2-(Hydroxymethyl)-, Methyl Ester, (1S- CAS NO 114498-10-1
CAS No.	114498-10-1
Molecular Formula	C6H11NO3
Molecular Weight	145.16 g/mol
Synonyms	(1S)-1-Amino-2-(hydroxymethyl)cyclopropanecarboxylic acid methyl ester; Methyl (1S)-1-amino-2-(hydroxymethyl)cyclopropanecarboxylate; (1S)-1-Amino-2-(hydroxymethyl)cyclopropanecarboxylic acid methyl ester; L-ACHC-OMe; (S)-Methyl 1-amino-2-(hydroxymethyl)cyclopropanecarboxylate; (S)-1-Amino-2-(hydroxymethyl)cyclopropanecarboxylic acid methyl ester; Cyclopropane amino acid derivative
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, critical for pharmaceutical applications. Quality is verified through advanced analytical techniques including HPLC, chiral chromatography, and NMR. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.