Description

Pentonic Acid, 2-Deoxy-2,2-Difluoro-4,5-o-(1-Methylethylidene)-, Ethyl Ester is a specialized fluorinated carbohydrate derivative, serving as a crucial advanced intermediate in modern synthetic chemistry. Its value lies in its unique difluoro and protected diol structure, enabling precise molecular modifications that are difficult to achieve with standard building blocks. This high-purity compound is essential for research and development chemists in the pharmaceutical and agrochemical sectors, particularly for the synthesis of novel nucleoside analogs and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel antiviral and anticancer nucleoside analogs, where the difluoro substitution mimics natural sugars to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging its fluorinated structure to improve compound efficacy and environmental persistence.
• Chemical Biology & Probe Development: Serves as a precursor for creating labeled sugars and molecular probes to study carbohydrate metabolism and enzyme mechanisms.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial production of complex active pharmaceutical ingredients (APIs).
• Academic & Industrial R&D: A valuable reagent for methodology development in organic synthesis, particularly in fluorination chemistry and protecting group strategies.

Basic Information

Product Name	Pentonic Acid, 2-Deoxy-2,2-Difluoro-4,5-o-(1-Methylethylidene)-, Ethyl Ester
CAS No.	114420-06-3
Molecular Formula	C12H18F2O5
Molecular Weight	280.27 g/mol
Synonyms	Ethyl 2-Deoxy-2,2-difluoro-4,5-O-isopropylidene-D-ribonate; 2-Deoxy-2,2-difluoro-4,5-O-isopropylidene-D-ribonic acid ethyl ester; 2-Deoxy-2,2-difluoro-4,5-O-(1-methylethylidene)-D-ribonic acid ethyl ester; Difluoro Isopropylidene Ribonate Ethyl Ester; Gemcitabine Intermediate; Advanced Fluorinated Sugar Derivative; Ethyl 2,2-Difluoro-4,5-O-isopropylideneribonate
EINECS	Contact for details

Quality Control

Our Pentonic Acid, 2-Deoxy-2,2-Difluoro-4,5-o-(1-Methylethylidene)-, Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity, meeting the stringent requirements for advanced pharmaceutical intermediates. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.