Description

tert-Butyloxycarbonyl-Valyl-α-Methylserine Methyl Ester is a protected dipeptide derivative, serving as a crucial building block in advanced organic synthesis. Its primary value lies in providing a versatile and reactive intermediate for constructing complex peptide chains and peptidomimetics with precise stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly in the development of novel therapeutic agents and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block for the solid-phase and solution-phase synthesis of complex peptide-based drugs and peptidomimetics.
• API Development: Used in research and development for creating novel Active Pharmaceutical Ingredients (APIs) targeting various diseases.
• Bioconjugation: Serves as a linker or spacer molecule in the synthesis of antibody-drug conjugates (ADCs) and other bioconjugates.
• Protease Inhibitor Synthesis: A critical precursor in the manufacture of protease inhibitors and other enzyme-targeting therapeutic compounds.
• Chemical Biology Research: Employed in academic and industrial research to study protein-protein interactions and develop biochemical probes.
• Custom Peptide Synthesis: Provides a protected valine and modified serine residue for the custom synthesis of specialized peptide sequences.

Basic Information

Product Name	tert-Butyloxycarbonyl-Valyl-α-Methylserine Methyl Ester
CAS No.	114396-65-5
Molecular Formula	C16H30N2O6
Molecular Weight	346.42 g/mol
Synonyms	Boc-Val-α-MeSer-OMe; Boc-Val-(α-Me)Ser-OMe; N-(tert-Butoxycarbonyl)-L-valyl-O-methyl-L-threonine methyl ester (related isomer); (2S)-2-[[(2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-methylbutanoyl]amino]-3-methoxy-2-methylpropanoic acid methyl ester; Boc-L-Valyl-L-α-methylserine methyl ester; N-Boc-L-valyl-L-α-methylserine methyl ester; tert-Butyl (2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-methoxy-2-methylpropanoate; Protected Valyl-Methylserine Ester
EINECS	Contact for details

Quality Control

Our tert-Butyloxycarbonyl-Valyl-α-Methylserine Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and reactivity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.